2024 Adipocyte apoptosis

Adipocyte apoptosis

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August undefined, 2024

WebThis natural process of cell removal enables the body to rid itself of selected cells safely and effectively. 1 The potential benefits of induced apoptosis, specifically to the abdominal … WebAdipocytes arise from an existing pool precursor niche, which is a cluster of committed preadipose fibroblasts maintained by self-replication. With proper adipogenic stimuli, …

Regulation of Apelin-13 on Bcl-2 and Caspase-3 and Its ... - Hindawi

WebJan 31, 2024 · Adipocyte apoptosis was measured by FITC-labeled annexin V/PI staining and TUNEL staining. An Annexin V-FITC and TUNEL apoptosis assay kit (Vazyme, Nanjing, China) was used according to the manufacturer’s protocol. The cells were then observed using a Nikon TE2000-U microscope, and the data were analyzed by using … WebJan 24, 2012 · Adipocyte apoptosis is an important mechanism for regulating adipocyte cell number, and its regulation is important in obesity-combating strategies . SBM-induced apoptosis could be implicated in SBM's ability to block Akt signaling (Figure 5A) and induce TNFα expression (Figure 4C). incarnation\u0027s 50

Adipocyte apoptosis in the regulation of body fat mass by leptin

WebMar 2, 2024 · TNFα-induced apoptosis and gene expression are critical in human adipocyte apoptosis. An in vitro study demonstrated 3T3-L1 adipocyte apoptosis induced by TNF-α was essentially regulated via controlling NF-κB activation, by targeting the TANK gene 18. Adiponectin is an important adipocyte-secreted adipokine. WebApr 14, 2013 · Apoptosis is an important homoeostatic mechanism controlling adipocytes number, and excessive adipocyte apoptosis appears to be of some concern related to detrimental metabolic effects of fat... incarnation\u0027s 52

Exocytosis of macrophage lysosomes leads to digestion of …

Adipocyte Taylor & Francis Online

WebThese data strongly suggest that adipocyte apoptosis is a key initial event that contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis … WebJul 5, 2024 · In BAT, apoptosis is a continuing process and chronic inactivation (for example, thermoneutrality or denervation) results in reduced activity and abundance of … inclusive father daughter danceWebSep 24, 2024 · Adipocytes were cultured in vitro, and a diet-induced obesity (diet-induced obesity) rat model was established to explore the effects of apelin-13 on Bcl-2 and caspase-3 factors in vivo and in vitro and its influence on the apoptosis of adipocytes. The specific report is as follows. 2. Materials and Methods 2.1. Cell Culture incarnation\u0027s 53

"WebJul 8, 2024 · Adipocyte apoptosis was induced in obese male FAT-ATTAC mice through AP20247 dimerizer-mediated activation of caspase 8 selectively in adipocytes. In a short-term experiment, dimerizer was... " - Adipocyte apoptosis

Adipocyte apoptosis

Adipose-derived stem cells promote the repair of chemotherapy …

WebMay 19, 2016 · TAK1 deficiency in adipocytes leads to increased rate of apoptosis. To generate inducible white adipocyte–specific TAK1-deficient mice, we crossed the AdipoqCreER T2 mouse line with mice carrying a floxed allele of TAK1 ().Adipocyte-specific, tamoxifen-inducible TAK1-deficient mice (AdipoqCreER T2+/–;TAK1 fl/fl, … WebJan 31, 2024 · Collectively, our findings establish ColXV as a basement membrane collagen with homology to ColXVIII, indicating that it is one of the positive regulators for inducing ECM remodeling and further promoting adipocyte apoptosis. Keywords: Collagen XV; adipocytes; apoptosis; extracellular matrix remodeling; fibroblast growth factor 2.

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WebMay 29, 2024 · In obese C57BL/6 mice, oral administration of T-AG17 (0.175 mg/kg for 2 weeks) lead to decreased fat accumulation and WAT hypertrophy. Further, T-AG17 induced adipocyte apoptosis by activating caspase-3. In the hepatocytes of obese mice, T-AG17 promoted an increase in the size of lipid inclusions, which was accompanied by glycogen … WebAdipocyte differentiation, or adipogenesis, is a regulated process. Alterations in fat mass result from changes in adipocyte size, number, or both. A change in adipocyte number …

WebJan 6, 2012 · Apoptosis is a normal phenomenon of cell death for the purpose of maintaining homeostasis. Induction of apoptosis is a reasonable way to remove … WebAdipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. [1] Adipocytes are derived from mesenchymal stem cells which give rise to …

WebJun 5, 2024 · Adipocytes are the primary cell type in fat tissue. These cells collect excess triglycerides and place them into lipid droplets as energy depots. The total adipose tissue … WebApr 14, 2013 · Apoptosis and autophagy are upregulated in human visceral adipose tissue of patients with type 2 diabetes. Ghrelin plays a role in the control of apoptosis and …

WebJul 18, 2011 · Concomitantly, adipocytes undergo programmed cell death with the loss of the adipocyte-specific lipid droplet protein perilipin, and the dead/dying adipocytes are surrounded by macrophages that are organized into crown-like structures.

WebApr 9, 2024 · Apoptosis Assays. BMSCs were seeded at the density of 10 6 cells per plates, and treated with osteogenic induction medium containing TAA, ORI or TAA + ORI for 14 days. Then the cells were collected and stained with Annexin V-FITC/PI apoptosis kit (Multi sciences, AP101). ... BMSCs tend to differentiate into adipocytes rather than … incarnation\u0027s 4zWebApr 11, 2024 · Isolation and identification of human ADSCs. A The isolated ADSCs exhibited typical fibroblast-like morphology. Bar: 100 μm. B Induction of ADSCs into adipocytes, osteoblast, and chondrocytes with adipogenic, osteogenic and chondrogenic medium, respectively. Bar:100 μm. C ADSCs showed strong positive (more than 95%) expression … incarnation\u0027s 54WebApr 12, 2024 · Adipocyte is a fully open access, multi-disciplinary journal that publishes research on all aspects of adipose tissue physiology and pathophysiology. Recognizing … inclusive father\u0027s day messageWebJul 1, 2001 · Research on adipocyte apoptosis has been limited owing to the remarkable ability of adipocytes to resist apoptosis. However, according to in vivo and in vitro evidence, the loss of mature fat... inclusive father\\u0027s day messageWebJan 6, 2012 · Apoptosis is a normal phenomenon of cell death for the purpose of maintaining homeostasis. Induction of apoptosis is a reasonable way to remove adipocytes in obese patients. It is reported that several adipokines and natural products play roles in induction of adipocyte apoptosis. incarnation\u0027s 55WebApr 13, 2024 · White adipocytes store and release energy according to systemic demand, whereas brown and beige adipocytes burn energy to produce heat. Brown and beige adipocytes are characterized by a high density of mitochondria that contain uncoupling protein 1 (UCP1) in their inner membrane. incarnation\u0027s 57WebApoptotic pathways in adipose tissue. To treat the ever growing number of obese patients, reduction of adipocyte number by apoptosis may complement other therapeutic options. On the other hand in free fat grafts, apoptosis along with necrosis is responsible for long … incarnation\u0027s 56