2024 Glucocorticoid receptor and adipocyte biology

Glucocorticoid receptor and adipocyte biology

Author: urbt

August undefined, 2024

WebDexamethasone (DEX), a synthetic ligand for glucocorticoid receptor (GR), is routinely used to stimulate adipogenesis in culture. GR-depleted preadipocytes show … WebDec 28, 2024 · Fat deposition is one of the important economic characters of pigs. Adipose tissue is mainly composed of mature adipocytes, which are distributed throughout the animal body and play a critical role in energy metabolism and homeostasis [1,2].Although adipose tissue is significant for maintaining the energy metabolism of animals, excessive …

Forkhead box A3 mediates glucocorticoid receptor function in …

WebDexamethasone (DEX), a synthetic ligand for glucocorticoid receptor (GR), is routinely used to stimulate adipogenesis in culture. GR-depleted preadipocytes show adipogenesis defects 1 week after induction of differentiation. However, it has remained unclear whether GR is required for adipogenesis in vivo. WebThe adipocyte is one cell type that contributes to whole body metabolic homeostasis under the influence of GR. Glucocorticoids' functions on adipose tissues are complex. … lodge #12 cast iron dutch oven

The glucocorticoid receptor: cause of or cure for obesity?

WebMar 24, 2012 · This recent evidence finally moved MR out of the shadow of the glucocorticoid receptor (GR), which had previously been considered the only player … WebJan 16, 2014 · Adipocyte and Cell Biology. The glucocorticoid receptor, not the mineralocorticoid receptor, plays the dominant role in adipogenesis and adipokine … WebApr 4, 2024 · Liu et al. reveal that glucocorticoids directly induce cellular senescence of bone-marrow adipocytes (BMAds) through a prostaglandin-PPARγ-INK positive feedback loop. The senescent BMAds trigger a secondary senescence in the surrounding bone cells by producing senescence-associated secretory phenotype (SASP) factors, leading to … indirect sources apa

Adipocyte Mineralocorticoid Receptor - ScienceDirect

Glucocorticoid Receptor Accelerates, but Is Dispensable for ...

WebOct 1, 2024 · Adipocyte glucocorticoid receptor plays a surprisingly minor role in obesity-induced insulin resistance. ... Molecular Biology of the Cell, 19 (10) (2008), pp. 4032-4041. View in Scopus Google Scholar [4] E.D. Rosen, O.A. MacDougald. Adipocyte differentiation from the inside out. WebApr 10, 2024 · Studies trying to clarify the relevance of GR in AT's biology used models of GR knockout; namely, regarding adaptive thermogenesis, most of them were focused on BAT. ... Adipocyte glucocorticoid receptor deficiency attenuates aging- and HFD-induced obesity and impairs the feeding-fasting transition. Diabetes, 66 (2024), pp. 272-286. indirect source mla citationWebNov 22, 2024 · Adipocyte accumulation in the bone marrow is a detrimental effect of GC treatment, resulting in high blood pressure, and collapse of vessels with consequent osteonecrosis in the femoral head. ... The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: Molecular mechanisms for gene … indirect sorting

"WebUniversity of Chicago Medicine. 2008 - 20124 years. Chicago, IL. Implicated the novel endocrine disrupting compound, tolylfluanid, in the global obesity and diabetes epidemics by characterizing ... " - Glucocorticoid receptor and adipocyte biology

Glucocorticoid receptor and adipocyte biology

WebNov 21, 2024 · The glucocorticoid receptor (GR) is an evolutionally conserved nuclear receptor superfamily protein that mediates the diverse actions of glucocorticoids as a ligand-dependent transcription factor. … WebAug 7, 2024 · Adipose Tissue Biology. AT is a major organ for energy storage and release throughout the body. There are two major types of AT: the white adipose tissue (WAT) and the brown adipose tissue (BAT). ... Roh H.C., Kumari M., Rosen E.D. Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to …

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WebSep 26, 2024 · This study shows that the glucocorticoid receptor in brown adipocytes plays a negligible role in systemic metabolism and BAT function, thereby opposing a long-standing paradigm in the field. UCP1-GR knockout mice do not suffer from impaired cold tolerance. BAT GR in brown adipocytes is dispensable for the adaptation to fasting … WebFeb 15, 2016 · Glucocorticoid hormones (GCs) are important regulators of lipid metabolism, promoting lipolysis with acute treatment but lipogenesis with chronic …

WebJul 23, 2008 · Glucocorticoid Receptor and Adipocyte Biology. 28 September 2024 Nuclear Receptor Research, Vol. 5. SCARA5 plays a critical role in the commitment of mesenchymal stem cells to adipogenesis. 1 November 2024 Scientific Reports, Vol. 7, No. 1. Prep1 prevents premature adipogenesis of mesenchymal progenitors. WebFeb 2, 2016 · CORTICOSTEROID RECEPTORS AND OBESITY. Although it is established that extended exposure to GCs causes abdominal obesity and Cushing's syndrome (see …

WebJan 1, 2024 · Mineralocorticoid receptor (MR) has been recently identified in adipose tissue, where its excessive activation contributes to several metabolic derangements often observed in obesity and metabolic syndrome.Recent findings support the existence of a bidirectional cross-talk between adipose tissue and adrenal glands, contributing to … WebMar 24, 2012 · This recent evidence finally moved MR out of the shadow of the glucocorticoid receptor (GR), which had previously been considered the only player mediating corticosteroid action in adipose tissue. ... Finally, several studies have implicated MR signaling in adipocyte biology (Urbanet et al., 2010, Caprio et al., 2007, Caprio et …

WebNov 19, 2024 · Despite an increasing number of studies focused on the adipocyte glucocorticoid receptor (GR), its precise role in the molecular mechanisms of these complications has not been elucidated. ... These discrepancies may rely on the murine model of constitutive GR invalidation that could profoundly modify the biology of adipose …

WebBecause of their powerful anti-inflammatory and immunosuppressive actions, glucocorticoids are one of the most widely prescribed drugs in the world today (3, 4).Synthetic glucocorticoids have been indispensable over the last half century for treating inflammatory and autoimmune diseases, such as asthma, allergy, sepsis, rheumatoid … indirect sourcing godarWebApr 30, 2014 · The role of MR has been studied in adipocyte cultures and in murine models of obesity. MR activity has been shown to promote expression of adipocyte markers and stimulate differentiation of 3T3-L1 ... indirect sourcing examplesWebWhile many studies examine if maternal environmental challenges are linked to changes in adiposity or adipocyte biology in the offspring, the mechanisms underlying these programming impacts remains largely unknown. ... Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activation ... indirect soundWebMar 1, 2014 · In addition, the type 1 glucocorticoid receptor, MR is expressed in adipose tissue, and mediates several actions of GCs. The molecular complexity in GR biology in … indirect sources of water pollutionWebMar 8, 2016 · Significance. This paper shows a previously unidentifed relationship between the transcription factor forkhead box a3 (Foxa3) and the glucocorticoid receptor (GR) by demonstrating, for the first time to our knowledge, that Foxa3 is a target of GR and that it is required for GR transcriptional function in fat depots. indirect sources are cited by mlaWebSep 21, 2012 · Glucocorticoids and androgens are important regulators of adipose tissue function. A new study by Hartig et al. in this issue of Chemistry & Biology provides relevant information regarding androgen receptor activity and its link to glucocorticoid action in human adipocytes during the process of preadipocyte differentiation. indirect sourcingWebNov 12, 2024 · The levels of circulating glucocorticoids are tightly controlled by feedback inhibition via proper activation of glucocorticoid receptor (GR) signaling in the hypothalamus and pituitary glands. This is due to activated GR signaling suppressing the expression of CRH, ACTH, and subsequently glucocorticoid secretion, thereby … lodge 12 inch cast iron wok