WebMay 17, 2004 · The interaction of cancer cells with laminin is a key event in tumor invasion and metastasis (2, 3, 10). One of the mechanisms by which laminin contributes to the … WebJan 20, 2024 · Brain metastases are known to be one of the most common intracranial tumors, outnumbering primary brain tumors by fourfold. Primary tumors that frequently …
Laminin-induced signaling in tumor cells - PubMed
WebJan 25, 2006 · Overexpression of the laminin γ2 chain by tumor cells, as well as lowered or impaired expression of the laminin α3 and/or β3 chains, may contribute to the loss of BM … jm weston oxfords
Laminin-induced signaling in tumor cells - ScienceDirect
WebLaminin α2-related dystrophy, MDC1A, also referred to as merosin deficiency, is caused by AR mutations in the LAMA2 gene on chromosome 6q. This form presents at birth with hypotonia, respiratory failure, and contractures. Serum CK is elevated and brain white-matter changes are observed on MRI T2-weighted sequences. WebApr 15, 2008 · Laminin-332, a large molecule consisting of α3, β3, and γ2 chains ( 7 ), shows widespread expression in many epithelial tissues, as well as in the tumor microenvironment of many carcinomas ( 8 ). In particular, several recent findings suggest that laminin-332 plays a crucial role in human SCC progression. Laminin-111 is a major substrate along which nerve axons will grow, both in vivo and in vitro. For example, it lays down a path that developing retinal ganglion cells follow on their way from the retina to the tectum. It is also often used as a substrate in cell culture experiments. See more Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major components of the basal lamina (one of the layers of the basement membrane), the protein network foundation for most cells and organs. … See more In humans, fifteen laminin trimers have been identified. The laminins are combinations of different alpha-, beta-, and gamma-chains. • Five alpha-chain isoforms: LAMA1, LAMA2, LAMA3 (which has three splice forms), LAMA4 See more Together with other major components of the ECM, such as collagens and fibronectin, laminins have been used to enhance mammalian cell culture, especially in the case of pluripotent … See more Laminins contain several conserved protein domains. Laminin I and Laminin II Laminins are … See more Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. … See more Dysfunctional structure of one particular laminin, laminin-211, is the cause of one form of congenital muscular dystrophy. Laminin-211 is composed of an α2, β1 and γ1 chains. This laminin's distribution includes the brain and muscle fibers. In muscle, it binds to See more • Laminin domain I: all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5) • Laminin domain II: all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5) • Laminin B (domain IV): all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5), … See more jm weston marais